Anti-KLRK1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss
BOSSBS-0938R-A488EA 441 EUR
BOSSBS-0938R-A488
Anti-KLRK1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antibodies
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: KLRK1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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