Ultrapure 1,5-diaminonapthalene (DAN) is an important matrix used in peptide and protein analysis by matrix assisted laser desorption ionisation (MALDI) mass spectrometry. The matrix is effective in promoting reduction of disulfide bonds in the gas phase, which greatly facilitates analysis of proteins and peptides containing disulfide linkages.
- Improves CID fragmentation of proteins with disulfide linkages
- Enhances in-source fragmentation of peptides
- Easy reconstitution directly in vial for ready to use stock
Research applications include MS and MS/MS analysis of peptides and proteins with disulfide linkages, peptide analysis in ISD (In Source Decay) experiments and analysis of gangliosides by MALDI-MS.