Dr. Ken Cook’s began his career in academia as a Biochemistry lecturer focused on protein chemistry and metabolism. Today, with well over thirty years’ industry experience working for Dionex, then Thermo Fisher Scientific, his vast knowledge supporting and developing solutions within chromatography brand him a bio-separations expert.
Ken’s work covered several application fields with a variety of analytical equipment. Initially using HPLC, Ion chromatography, SFC and capillary electrophoresis to develop new methods of analysis. This was a strong analytical introduction with multiple orthogonal techniques. Following his move into a Bio-Separations role with metabolomics, lipodomics and proteomics with nanoLC, all coupled to several MS systems. This work has always included strong collaborations with other groups throughout Europe and the supervision of several PhD studentships. Publications have been in a number of diverse fields including environmental, oil, food safety and adulteration, Proteomics, Protein chemistry, metabolomics and lipodomics.
Currently, his work involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide-based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Methods for the characterisation of therapeutic proteins include peptide mapping by LC/HRMS. Developments in charged variant analysis including novel coupling to MS, Glycan analysis, Aggregate analysis and on-line process monitoring. Gene therapy characterisation is a growing interest which has had much success.